The most harmonious thing would be 36 teams with six six team divisions.
My Modest Proposal
Eastern Conference
Atlantic Division (teams brutalizing each other)
PHL
NYM
NYY
BOS
WAS
BAL
Northeast Division (small markets galore)
TOR
MTL
BUF
PIT
DET
CLE
Southeast Division
CIN
NSH
CHAR
ATL
MIA
TB
Western Conference
Midwest Division
CHI C
CHI WS
MIN
MIL
STL
KC
Southwest Division
HOU
TEX
COL
ARI
LV
SLC
Pacific Division
LAD
LAA
SD
SF
SEA
POR
Of course, ther zillion dollar question is whether there is enough baseball talent--and more, specifically, pitching--on the planet to sustain this.